Donghua Zhou

Our biological physics research focuses on proteins important to health. We use both solution and solid state NMR experimental techniques to study the structure and dynamics of soluble, aggregated, and membrane proteins. Atomic resolution three-dimensional structures of proteins are critical to understand their biological functions and molecular mechanisms of diseases. We also use supercomputer based molecular docking and molecular dynamics (MD) simulation methods to study interactions of potential drug candidates with target proteins, providing important insights on how to redesign molecules for more potent drugs with less side effects.